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60 y/f with history of breast ca and had segmental mastectomy sereral years ago in other hospital. Patient present with pleural effusion.
F1. ThinPrep 400x
F2. cell block 400x
F3-4. cell block 600x
What will you do?
First step:
I always do some stains for these kinds of fluid cytologic cases to distinguish mesothelial cells from epithelial cells first.
Calretinin (mesothelial) and BerEP4 (epithelial)are the best two markers to choose.


| 以下是引用笃行者在2010-1-1 21:19:00的发言:
对细胞学不是太熟悉,但感觉这些细胞核较大,核浆比增大,染色质较粗,核仁明显,有核分裂像,考虑是癌细胞。期待Dr.zhao解惑,谢谢! HAPPY NEW YEAR TO YOU, Dr.Zhao. |
We sent message here in the same time. You just did a few second before me.
Happy New year to you too. Thank you I learned the new word "笃" in 2009. cz
| 以下是引用cqzhao在2009-12-31 11:21:00的发言:
This is my last case in 2009. Thank all people who read and/or attended discussion for these cases. HAPPY NEW YEAR FOR ALL OF YOU. CZ |
HAPPY NEW YEAR TO YOU,Dr.Zhao.
这例在血细胞、炎症细胞的背景下,可见增生的间皮细胞。需要关注的是,极少的核膜增厚的染色质增粗的核仁增大的细胞,可能是问题细胞。建议利用细胞块做IHC标记D2-40、TTF-1等间皮与腺标记物,以鉴别。
